Did Blender Blur AdEdit Line

first_imgSince its inception in 1999, Blender magazine has tried to distinguish itself as an alternative to the Rolling Stone establishment of rock journalism.Now it appears to be following Rolling Stone in blurring the advertising-editorial line.In its January-February issue, Blender published the “2008 Rock & Roll User’s Guide,” a 16-page new music preview sponsored by Sync, Microsoft’s in-car voice-activated technology. In it, a small logo that reads “Presented by Sync/Powered by Microsoft” appears on five of the section’s 10 editorial pages, with the other six pages devoted to Sync-related ads. Four of those logos ask readers to log onto fordvehicles.com/sync for free MP3 downloads. “I would say that this is a clear violation of our guidelines,” American Society of Magazine Editors executive director Marlene Kahan told FOLIO: on Monday. According to the American Society of Magazine Editors, “sponsorship language (ie, “sponsored by,” “presented by,” etc.) should not appear in connection with regularly occurring editorial features” unless the editorial content “is labeled ‘Advertisement’ or ‘Promotion’ in a type size as prominent as the magazine’s normal body type.” [SEE: ASME Guidelines.]A spokesperson for Blender said the section was purely editorial and that the preview was written prior to selling the sponsorship. A spokesperson for the Alpha Media Group, the owner of Blender and Maxim, declined to comment on the details of the sponsorship, and said that the company is commited to adhering to the guidelines set forth by ASME.The Blender feature comes on the heels of a class action lawsuit filed by 185 indie rock bands in December against Rolling Stone over a sponsored nine-page pull-out spread that the bands said used their names without permission.Five of those bands represented in the class action suit appear in the Blender preview. Representatives for My Morning Jacket, one of the bands appearing in both, declined to comment.The Rolling Stone suit followed a separate lawsuit filed by attorney generals in eight states against R.J. Reynolds—the section’s sponsor—claiming the company illegally used cartoons in an advertorial to sell cigarettes. Rolling Stone said the cartoons were part of its editorial treatment—and not R.J. Reynolds’ idea.RELATED DISCUSSION: Does Anyone Care About ASME Guidelines?last_img read more

McDonalds halal meat sparks row on Twitter netizens threaten to boycott food

first_imgSharia compliance? Why McDonald’s Why? Jhatka is the new thing! Should have gone with Jhatka meat McDonald’s is facing severe criticism over their tweet for serving halal meat.Getty images- Justin Sullivan / StaffThe fast-food chain McDonald’s has got itself tangled in a religious matter and is being grilled on social media after they tweeted to one of its customers saying that the chain only serves “halal meat”.”All our restaurants have HALAL certificates. You can ask the respective restaurant Managers to show you the certificate for your satisfaction and confirmation,” tweeted McDonald’s India. The tweet has sparked a lot of controversies by several sects of people that it became a trending topic on Twitter.This tweet from McDonald’s India came as a response to another Twitter user’s (hibailyas89) query On Thursday, August 22. The user asked McDonald’s whether their restaurants in India have a halal certificate.McDonald’s is facing severe criticism over their tweet for serving halal meat that several netizens have started a social media campaign for boycotting the restaurant chain. #BoycottMcDonalds has become a major trend on Twitter where social media users have called out McDonald’s for serving halal meat in a country, where the Muslim population is a minority.Many people have also come up asking for Jhatka (Chatka) meat rather than having halal meat. Jhatka is the meat from an animal killed instantaneously, such as by a sword or axe to sever the head and is associated with this kind of animal slaughter in the Hindu and Sikh traditions.Here’s how Twitterati reacted:-Forcefully Halal?last_img read more

Firstlook Vijay Varma turns 90s student for Hurdang

first_imgVijay Varma is a name that needs no introduction. Delhi Belly, Dedh Ishqiya, Monsoon Wedding and the latest Gully Boy is a testimony to the powerhouse performer he is. Sinking into the skin of the character, Vijay Varma brings out any character with utmost authenticity and honesty. In continuation of the trend, Vijay Varma has transformed himself as a college student from the 90s for his film – Hurdang.Acing the part of a 90s college student from Allahabad, Vijay is doing his best to add his own nuances to the character. The actor who is currently working on Hurdang in Prayagraj. He is feeling the thrill of working on a period film and though the film isn’t a classic period film, the fact that it’s set in the 90s requires major prep from him, a challenge he has taken up well enough.From understanding the social scenario of the era to its very politics, the actor has undergone a makeover after a few rounds of changes. To be era authentic, Vijay has even grown a moustache. Depending on his character requirement and background, Vijay decided to have a cleaner look. Vijay went through a series of look tests, exchanged notes with the director on how to add to his look.The actor says, “We arrived at the final look after many trials. We wanted to get the milieu right and took references from many real-life personal pictures from the late 80s which the team had gathered for mood boarding.””Sheetal Sharma is the designer on this film and we worked closely over many trials to get the vibe of Loha Singh right. Power and leadership are his main trials and we made sure it reflects in the styling. The script has a lot of answers in explaining the political scenarios of the 1990 and what was the general sense of response by these characters to the times they were living in. Discussions and looking up on history helped in making it more nuanced instead of settling for a uni-dimensional approach to the period,” Varma added.last_img read more

3 Apan Jewellers owners sent to jail

first_imgProthom Alo File PhotoA day after issuing warrants for the arrest of three owners of Apan Jewellers, separate courts here on Tuesday sent them to jail in five cases filed for laundering money and dodging tax, reports UNB.Four metropolitan magistrates — Nurunnahar Yeasmin, Satyabrata Shikder, Mazharul Haq and Ahsan Habib — passed the orders when Dildar Ahmed and his two brothers — Gulzar Ahmed and Azad Ahmed — surrendered before the courts seeking bail.Of them, Dildar was sent to jail in three cases filed with Dhanmondi, Ramna and Uttara police stations while his brothers in two cases filed with Gulshan police station.Earlier, Dhaka metropolitan magistrate Nur Nabi issued a warrant on Monday for the arrest of Dildar Ahmed as he did not appear before the court on expiry of his bail granted by the High Court in two cases filed under the Money Laundering Prevention Act and for accumulating illegal wealth.Besides, Dhaka metropolitan magistrate Nurunnahar Yeasmin issued warrants for the arrest of two other owners of the jewellery brand — Gulzar Ahmed and Azad Ahmed – on the same charges on Sunday in the two cases.On 22 August, an HC bench granted anticipatory bail to the three brothers in the two cases filed against them.On 12 August, Customs Intelligence and Investigation Directorate (CIID) filed five cases against the three owners of Apan Jewellers after 15 maunds of illegal gold and some diamond jewellery were recovered from its branches.Five CIID assistant revenue officers filed the cases with Gulshan police station, Dhanmondi police station, Ramna police station and Uttara police station following directives of the National Board of Revenue (NBR).Apan Jewellers hit the limelight after the rape of two private university girls by Shafat Ahmed, son of Dildar Ahmed, and his cohort in a Banani hotel came to the fore.One of the rape victims filed a case with Banani police station on 6 May last accusing five people, including Shafat.last_img read more

N Zealand expels US diplomat

first_imgA US diplomat has been expelled from New Zealand after Washington refused to waive diplomatic immunity so police investigating a serious crime could question him, officials said.Details of the alleged crime have not been revealed but local media reported the diplomat left the South Pacific nation last week suffering a broken nose and black eye.Foreign Affairs Minister Murray McCully said he was “disappointed” at the US refusal to waive immunity and in response asked for the person’s withdrawal from New Zealand.”Officials in Wellington and our ambassador in Washington DC have clearly conveyed to the United States the expectation that foreign diplomats obey the law in New Zealand and are seen to face justice in New Zealand,” he said in a statement released to AFP Monday.Police said they were called to an incident in Lower Hutt, on Wellington’s outskirts, in the early hours of March 12, which “involved an individual from the US embassy in Wellington”.By the time they arrived the person had left the scene and no arrests were made.Attempts to further investigate hit a diplomatic brick wall.McCully said foreign affairs officials relayed a police request to waive immunity but their US counterparts refused.Local media named the diplomat as Colin White and said he left Wellington with his wife and children.TVNZ, which broke the story, reported that White was a technical attaché who had been working closely with New Zealand’s intelligence service, the GCSB.A spokeswoman for the US embassy said they were “communicating with New Zealand authorities” on the issue.”As a matter of policy, we do not comment on the specifics of matters under investigation,” she said in a statement.”We take seriously any suggestion that our staff have fallen short of the high standards of conduct expected of US government personnel.”McCully said the US had stated it always fully investigated all allegations involving its diplomatic staff.Diplomatic immunity, formalised in the 1961 Vienna Convention, means foreign envoys are protected from local law enforcement in the country to which they are posted.The most recent known case of it being invoked in New Zealand was in 2014, when Malaysian military attaché Mohammed Rizalman bin Ismail was accused of indecent assault.It was eventually revoked and Rizalman was sentenced to nine months’ home detention after being found guilty in a Wellington court.last_img read more

14 killed as mortars hit Afghan market

first_imgAt least 14 people were killed and dozens more wounded when a busy market in northern Afghanistan was hit by mortar fire, officials said Saturday.Several Taliban shells hit the market Friday morning in the Khwaja Sabz Posh district of Faryab province, according to Hanif Rezaee, an Afghan army spokesman.”Fourteen civilians were killed and 40 — including women and children — were wounded,” Rezaee told AFP.He said the Taliban had been trying to hit an army checkpoint near the market. The insurgent group did not immediately comment.Naem Musamim, Faryab’s public health director, said 14 bodies and 39 wounded people including four children had been taken to local hospitals.Some victims with critical injuries were airlifted to hospitals in Mazar-i-Sharif in Balkh province.The deadly incident comes as the war between the Taliban and Afghan security forces rages on, even as Taliban officials are meeting with US negotiators in Doha in a bid to bring about an end to the conflict.On Sunday, the insurgents will meet in the Qatari capital with various representatives from Afghan society as part of a potential peace process.last_img read more

Electron crystallography found to work as well as Xray crystallography only on

first_img Innovative technique to analyse mesoscopic materials directly © 2018 Phys.org Two teams working independently have shown that electron crystallography can work as well on smaller crystals as X-ray crystallography does on larger crystals. The first team was made up of members from several institutions in Switzerland and Germany—they have published a paper describing their work in Angewandte Chemie. The second team was made up of members from the University of California and the Howard Hughes Medical Institute—they have uploaded a paper describing their work to the ChemRxiv preprint server. Both teams used similar methods in their work, and both used it to show the structure of over-the-counter medicines. Explore further Until now, chemists have had two main tools to discern the structure of crystals. The first, and most often used, is X-ray crystallography. In this approach, X-rays are fired at a crystal and researchers note the diffraction patterns to determine the crystal’s chemical structure. The second tool, called nuclear magnetic resonance spectroscopy, works indirectly by disturbing the magnetic behavior in the atoms that make up a crystal and noting their behavior. The one main drawback of both of these tools is that they cannot be used to determine the structure of very small crystals. In this new approach, both teams replaced X-rays in the first tool with an electron beam to determine the structure of very small crystals. After firing at a crystal target, its structure can be determined by studying the resulting diffraction patterns.Both of the teams used the new approach to study the crystal structure of over-the-counter medicines to demonstrate how it can be used. They also both used the technique to study larger crystals—the team working in Switzerland used it to find the structure of a methylene blue derivative. The team at UoC did the same with thiostrepton.Both teams note that the technique is very quick and very accurate—and it only works with crystals. Also, it can only be used to study relative, not absolute stereochemistry. Both teams also note that widespread use of the technique is likely to be limited due to the cost of the equipment. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Identification of compounds from heterogeneous mixtures. EM grid prepared as above with biotin, brucine, carbamazepine, and cinchonine powders mixed together. All four compounds identified by unit cell parameters using MicroED data from within the same grid square. All structures were solved to ~1Å resolution. Grid holes are 2μm in diameter. Credit: ChemRxiv , Angewandte Chemie International Edition More information: Tim Gruene et al. Rapid structure determination of microcrystalline molecular compounds using electron diffraction, Angewandte Chemie International Edition (2018). DOI: 10.1002/anie.201811318The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination, ChemRxiv, chemrxiv.org/articles/The_Cryo … ermination/7215332/1 Journal information: Angewandte Chemie Citation: Electron crystallography found to work as well as X-ray crystallography only on smaller crystals (2018, October 24) retrieved 18 August 2019 from https://phys.org/news/2018-10-electron-crystallography-x-ray-smaller-crystals.htmllast_img read more

No encroachment beyond 50ft distance of crossings Hakim

first_imgKolkata: Mayor Firhad Hakim passed a clear message to the hawkers on Tuesday saying they should not encroach beyond 50 feet distance of the crossings in the city and that using of plastic is discarded while running the business.Hakim held a meeting with the affected hawkers in the Gariahat fire and several hawkers’ organisations in the presence of senior officials of police and Fire department. In and around 58 crossings in the city encroachment has become a big problem. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killed”They have been asked to remove the plastics used and the trolley-based stalls that they are due to get will have shed. We are planning to give them special type of umbrellas so that customers do not get drenched during monsoons. I have seen this type of umbrellas in Thailand that can be made here as well,” Hakim said. A model of the trolley-based stall which will be 5 to 6 feet long and 3 to 4 feet wide will be taken to Gariahat on Thursday so that the hawkers see and decide whether it is serving their purpose. “We are formulating hawkers’ policy to regulate them in the city. They have already agreed to only occupy one third space of the pavements. Police will demarcate the place and if they flout action will be taken as per law,” Hakim said. The Mayor said the one time compensation of Rs 20,000 to each of the affected hawkers will be directly transferred to the bank accounts through RTGS by the weekend. A list of the affected hawkers has been prepared by Gariahat police station.last_img read more

Microsoft Grounds Its AI Chat Bot After it Learns Sexism and Racism

first_img 2 min read March 24, 2016 This story originally appeared on Engadget Microsoft’s Tay AI is youthful beyond just its vaguely hip-sounding dialogue — it’s overly impressionable, too.The company has grounded its Twitter chat bot (that is, temporarily shutting it down) after people taught it to repeat conspiracy theories, racist views and sexist remarks. We won’t echo them here, but they involved 9/11, GamerGate, Hitler, Jews, Trump and less-than-respectful portrayals of President Obama. Yeah, it was that bad. The account is visible as we write this, but the offending tweets are gone; Tay has gone to “sleep” for now.”Tay” went from “humans are super cool” to full nazi in <24 hrs and I'm not at all concerned about the future of AI pic.twitter.com/xuGi1u9S1A— Gerry (@geraldmellor) March 24, 2016It's not certain how Microsoft will teach Tay better manners, although it seems like word filters would be a good start. The company tells Business Insider that it's making "adjustments" to curb the AI's "inappropriate" remarks, so it's clearly aware that something has to change in its machine learning algorithms. Frankly, though, this kind of incident isn't a shock -- if we've learned anything in recent years, it's that leaving something completely open to input from the internet is guaranteed to invite abuse. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Register Now » Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right.last_img read more

A34 closed overnight due to roadworks

first_imgGet the biggest Daily stories by emailSubscribeSee our privacy noticeThank you for subscribingSee our privacy noticeCould not subscribe, try again laterInvalid EmailA major North Staffordshire road will continue to be closed overnight for the next two evenings as roadworks continue. The A34 Stone Road will be shut in both directions between the A5035 Longton Road (Trentham Roundabout/Trentham) and the A51 (Dalraston Island/Meaford). The road is shut between 9pm and 5am on Thursday night (May 31) and Friday night (June 1), according to traffic data company INRIX, having previously been closed on Wednesday night. Staffordshire County Council are carrying out the works on the road. A Stoke-on-Trent City Council spokesman said motorists should factor the closure into their travel plans. He said: “Work is ongoing on the A34, Stone Road, at Meaford & the roundabout at Strongford. The road will be closed in both directions between points A and B (Image: Inrix) “Although this is not city council work, it is having an impact on our roads & your journey may take longer. “The road will be closed overnight tonight and tomorrow from its junction with the A5035 (Longton Road) to Meaford to allow these works to take place safely. “Diversion routes will be signed.” Read MoreFirst class! Post Office will deliver a new branch in town centre after community has been left without a facility for months Want to keep up to date with the latest traffic and travel news?Each day Stoke-on-Trent Live journalists bring you the latest news on the roads and railways across Stoke-on-Trent, North Staffordshire, South Cheshire and further afield to help keep you on the move. For the very latest updates on roads including the M6, A500, A50 and more, visit our dedicated traffic and travel news channel here. We also run a live news feed each weekday, which you can access on our website’s homepage from 7am to 9pm from Monday to Friday. And for more as-we-get-it updates on the roads across the region and beyond, join The Sentinel’s traffic and travel Facebook group here.last_img read more

Rep Alberts system to evaluate economic incentives headed to governor for consideration

first_img### 19Dec Rep. Albert’s system to evaluate economic incentives headed to governor for consideration The state House provided its final approval to Rep. Thomas Albert’s plan to determine the effectiveness of Michigan’s economic incentive programs, sending the measure to the governor for consideration.Albert’s measure would require the state to hire an independent outside contractor to evaluate and recommend changes to the state’s economic incentive programs, which generally provide business tax incentives with the goal of promoting job creation and economic development.“We owe it to taxpayers to study these programs thoroughly and determine whether they work in Michigan’s best interests,” said Albert, of Lowell, chair of the House Financial Liability Reform Committee. “Are these incentives worth the money Michigan invests or forgoes? The best way to truly find out is with an open, honest and complete evaluation from an independent reviewer.“Whether you lean for or against economic incentives in general, we should all be able to support this huge step toward an accountable and transparent government.”An independent analysis of each incentive program would help determine which programs should continue, which should be improved and which should be eliminated. Evaluations would determine whether stated goals of incentive programs are being met. Reviews also would consider economic impact and effects on other businesses, along with impact on the state budget.House Bill 6052 is now awaiting Gov. Rick Snyder’s review.center_img Categories: Albert News,Newslast_img read more

VGTRKbacked Russian thematic channel provider Dig

first_imgVGTRK-backed Russian thematic channel provider Digital Television Russia (DTR) is at MIPCOM for the first time this year as it looks to forge international partnerships for expansion into markets globally. Chairman Dmitry Mednikov talked to DTVE about the company’s plans.What is driving demand for your thematic channels within the Russian market and what genres have performed best?We work across many content genres and in all categories our channels are within the top-3 category. Twelve months ago we launched Moolt, a pre-school animation channel. Today this is the #1 kids channel in Russia, it preforms better than many other international kids channels who broadcast locally.DTR’s ‘Russian Romance’, a female skewed TV series and movies channel is another success story for us. We are traditionally strong in the factual content genre – we currently have an unmatched portfolio of seven channel brands, with ‘My Planet’ being the #1 factual channel. It continues to significantly outperform other international factual channels in Russia. Last year we rebranded T24 (Turbo channel) which now holds the fort as a younger male-skewed channel, with key content and programming genres focusing on airspace, military technology, auto and other flagship shows like Polygon, where hosts drive tanks or fly air-jets. Recently, we launched The ‘Living Planet’ channel which focuses on all thing wild life, and it performs extremely well for us.What further plans do you have to develop your offering for the domestic market over the coming year?We are constantly evolving as a local and international media business and invest research studies. We look at ‘audience preference’ and try to understand our hard-to-reach audience. We promote programming on the channel in the most appropriate way and try to understand the social trends in order to be in line with the coming changes.We are at MIP and all around the world to source and bring to domestic market the best content productions. We are very excited about production from new markets like Latin America, China and India.What brands, content and formats from your Russian properties can translate internationally and how do you plan to commercialise these? Will you focus on selling content, licensing formats or licensing channel brands, for example? What other products or activities could emerge from international partnerships?We are in the business of pay-TV, so we operate on a dual-revenue stream basis – affiliate revenue and advertising sales is our focus. All our linear content has digital extensions like VOD, mobile and internet rights. And we creating an exciting experience with social gaming. Licensing consumer products and content syndication is another strong plan for us. We target emerging middle-class audiences and local production on our channels is very important. We have strong Russian pay-TV brands which are showing high potential and strong market share. We are open to commercial discussion in producing international channels for a Russian diaspora outside of Russia.Linear channels – Moolt which will be ANI in Latin America. We are in the process of research and testing for India.T24 and our Living Planet channel is set become a successful younger male and family channel. The format for our Russian Romance channel is great for female-skewed audiences; and we created a new international channel brand for our foreign audiences which is based on Russian ballet, classical dance and fashion which we plan to introduce to Asia.Do you plan to market channel brands internationally as well as content formats, and, if so, which brands?We plan to come to market with MOOLT, Planeta Vivo (Living Channel) and SERIAMOR a (Russian Romance).In each region it is going to be local brands and local programming strategies.What specifically is planned from the collaboration with Prasar Bharati? Do you expect other markets to follow the same pattern?This is very big and important project for us. Being a commercial arm of VGTRK we have strong social responsibility. Hence the areas where we are collaborating with PBClosing the information gap between India and Russia. The more people in both countries know and understand about respective culture, technology, or business, the more educational, cultural, business, tourism exchange will all take place through this collaboration.New marketing and distribution opportunities will boost local production and will give an opportunity for Indian talent to introduce their content in Russia and vice versa.One of our partner company distributes ZEE Television portfolio in Russia and we see strong viewership growth and interest to Indian content in Russia. We are considering a partnership with BRIC programmers to grow our business domestically.DTR has best expertise in creating channels for emerging middle class and DTR is excited to collaborate with PB which owns the strongest local content library to produce pay TV channels in India. This is targeted for a growing Indian middle-class audience, which is expected to grow up to 40% in the next 5 years.What kinds of JV or partnership do you think will work best internationally in terms of the ownership structure, management etc.?All markets are different in terms of local requirements. Our key principle is equal rights and strong vote in decision making for everyone at the table, and we should bring additional value to each partner.You mention plans specifically for the Middle East and Latin America. What is your assessment of the opportunity in each of these markets and how can your offering be tailored for each?We are company which has the expertise to create content for middle-class audiences. DTR offers premium content at accessible rates. DTR’s growth drives overall pay-TV growth in Russia and it benefits the entire ecosystem. Pay TV market penetration is at 90% today compared to 31% 5 years ago when we launched our first channel – My Planet. Our portfolio allows our affiliates partners to form sub-basic local packages which are affordable. This is where we foresee as an opportunity for us as a programmer, to work in collaboration with Latin American operators to grow the market up to additional 30% which is somewhat flat today.last_img read more

Kul Chandra Gautam was born in a rural village wit

first_imgKul Chandra Gautam was born in a rural village with no electricity or running water, no doctors and schools. The nearest town with a market was a five-day walk away.He left home at age 7 to study — and study he did. He was one of the first people in the world to learn English from a Peace Corps volunteer, and his outstanding grades eventually won him a full scholarship to Dartmouth.But getting there wasn’t easy.For two years, Gautam petitioned the Nepali government for a passport so he could attend the U.S. university. But back in the 1960s, passports were given only to people of privilege — not poor villagers. His passport request went all the way up to the king, only to be denied.It was then Gautam vowed to do something special with his life.”That moment came because of the injustice of not being able to get a passport,” he said on a visit to NPR headquarters last month to talk about his life and his new memoir, Global Citizen from Gulmi: My Journey from the Hills of Nepal to the Halls of United Nations.Gautam, now 69, speaks with contagious energy, his eyes gleaming. (He exuberantly corrects the Western way of counting one’s age. He’s actually 70, he says, because in Nepal your first birthday is on the day you are born: “That seems logical to us!”)The discrimination Gautam faced as a young man only made him fight harder. The second time he applied for a passport, a mid-level government official who had also risen from a rural village sympathized with his plight and approved his application.Gautam was going to America.”From that point on, I felt — ah! I have managed to do something impossible,” he says early in the interview. His cup of tea, forgotten, cools before him as he recalls the pain and then joy of his challenges. “Even when the king rejects you, that’s not the end of the road.”For Gautam, the road would extend all the way to a top leadership position with the United Nations.In 1971, he graduated from Dartmouth, where he studied international relations, after just three years. Next, he received his master’s degree in economic development and modernization from Princeton University’s Woodrow Wilson School in 1973.After that, he ascended the ranks of the United Nations, beginning as a program officer for UNICEF and climbing to the position of assistant secretary general of the U.N. from 2000 to 2008.A grandfather’s wishWhen Gautam was born, his grandfather, who had long yearned for male heirs, was elated.”He said, ‘I want this boy to be someone special,’ ” Gautam recalls. ” ‘An educated pundit.’ “His grandfather and his father taught him all they knew, scratching letters of their Nepali dialect into the dirt with a stick. The boy quickly absorbed their knowledge. When he was 7 years old he moved to a village across the river to learn from a local teacher — the first in a series of moves farther and farther from home in the pursuit of education.In 1962, Gautam was a seventh-grader in a town called Tansen, one of the first outposts for volunteers with a new organization, the Peace Corps. Gautam knew only a few English words then — not enough to string together a sentence — but he excelled under the volunteers’ tutelage.His education didn’t stop when school did; Gautam would tag along with his teachers after class. They taught him how to play chess and Scrabble; soon enough, he began beating them.One volunteer told him if he kept up his education, he might one day study in America.There are times when the right encouragement, the right promise, echoes in your head and lodges in your heart. Even now, half a century later, Gautam’s face still lights up at the promise of that dream.The idea of studying in the United States stayed with him. More specifically, Gautam decided, he wanted to attend Dartmouth — the alma mater of a volunteer who had lent him books.In the final year of high school, Gautam enlisted the help of his old Peace Corps teachers and took college entrance exams.”Apparently, surprisingly, I did very well,” he says with characteristic humility. He still calls himself “a little village boy” and says that his village was, “by Nepali standards, not very remote” — a mere five-day walk to the nearest small city.At one point, he mentions in passing that he was one of the most accomplished students in all of Nepal. He was recounting his explanation to a low-level government employee why he should be granted the passport.”Obviously, he was suspicious, you know, ‘How did he get this scholarship? This is abnormal.’ And I explained everything, you know, I have a very good record in school, I’m at the top of the whole country in the final school-leaving exams.””But qualification is not the main criteria” for getting a passport, he says, shrugging nonchalantly. “There’s one possible criteria: It is who you are related to.”Yet this poor Nepali villager not only gained entrance to one of the most prestigious schools in the United States — he was offered a full scholarship.Gautam believes organizations like the Peace Corps, which was instrumental to his own education, are important for improving the lives of people like him around the world.”The Peace Corps is a unique instrument that I think is perhaps underestimated in this country and elsewhere,” he says. “They are in many ways the true ambassadors of the U.S.””He has such a great voice for his country,” says Glenn Blumhorst, president and CEO of the National Peace Corps Association. This year, Gautam was honored with the organization’s Harris Wofford Global Citizen Award.”He has the ability to connect with a village elder or a small child in his village, somebody who’s from very humble background, to diplomats and heads of state,” Blumhorst says. “That’s really impressive.”Hard work, good luckWhen he tells his story, Gautam is sure to emphasize his good luck along with his hard work and determination. But he also clearly has a faculty for winning people over.When he speaks of the government official who eventually helped him get a passport, he tugs on his ear just like the official did five decades ago — an impromptu sign for “Listen, here’s the way we have to do this,” a code between two villagers of how they’d work within the system to conquer it.At UNICEF, where he eventually became deputy executive director, Gautam was part of the push to vaccinate 80 percent of the world’s children by 1990 — an enormously ambitious and ultimately successful campaign.In addition to vaccines, UNICEF encouraged health workers to monitor children’s growth and introduced oral rehydration therapy to combat diarrhea and dehydration — a major killer of children.To encourage breastfeeding in places where unclean water caused many infections, like Brazil, Gautam enlisted the mother of soccer superstar Pelé.”Of course, he is the best football player in the world,” Pelé’s mother said, patting the shoulder of her son in an image that was plastered on billboards around the country. “I breastfed him!”All of these improvements have had a massive impact. But to reach the remaining children in need, Gautam says, global health and development workers must take a multi-pronged approach.”You do whatever you can do. It’s not one versus the other,” he says. “We vaccinate people, we also work on poverty reduction, we also work on girls’ education, we work on multiple fronts.”That last issue — girls’ education — is particularly important to Gautam.”Of the investments you can make in development,” he says, “probably the most important, and the most transformative, is in girls’ education.”It’s important not just because it changes each girl’s life, Gautam explains, but also because those changes ripple throughout the whole family and into the community. Education helps halt the cycle of poverty that often traps generations of families.”Ultimately, the best vaccine is reducing poverty and providing education,” he says.Gautam retired from the U.N. in 2008. He now serves as chair of the board of RESULTS, a nonprofit focused on eradicating poverty. He is optimistic about the progress the world has made battling preventable diseases and improving the well-being of millions around the globe. But, he points out, newer — and more complicated — problems arise as old ones are solved.For instance, when he was growing up, his village had no school. About 95 percent of men and 100 percent of women were illiterate. It was rare for a woman to receive any education, he says.Today, there are five primary schools in his village alone. And more girls than boys attend the public schools in his village, Gautam says.But for this longtime activist, access alone isn’t enough. “You see this new form of inequality coming — a subtle discrimination,” he says. More girls may attend public schools, but more boys attend higher-quality private schools, he believes. The girls have equal access to education, but not to equal quality, he says.”If the biggest challenge in development of the 20th century was access to basic services, the biggest challenge of this century is equity,” he says. “How do we make sure that everybody has access, [and] that access is equitable?”Melody Schreiber (@m_scribe on Twitter) is a freelance journalist in Washington, D.C. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

10 TSAApproved Travel Tips to Make Your Holiday Travel Easier

first_img Register Now » Next Article Learn how to successfully navigate family business dynamics and build businesses that excel. Travel 94shares Have a question about what you can bring with you on the plane this holiday season? @AskTSA has some suggestions. Image credit: Shutterstock Add to Queue This year, AAA is predicting that 50.9 million Americans will travel 50 miles or more away from home for Thanksgiving, a 3.3 percent  — in the form of 1.6 million people — increase from last year.The holiday travel season is particularly stressful gauntlet that the majority of us have to run every November and December, but there are tools to help simplify things — like the Transportation Security Administration’s @AskTSA Twitter account, which offers travel tips to make going through security as painless as possible.For a quick-hit of 10 holiday-related items TSA says you can and cannot bring with you on your travels, read on.Related: Why the TSA — Yes, the One at the Airport — Is Actually Amazing at Instagram1. Don’t bring wrapped presents.@VeevsVT Wrapped gifts are allowed but not encouraged, as they may need to be unwrapped if further inspection is required.— AskTSA (@AskTSA) November 5, 20172. You can, in fact, bring a turkey. We’re glad you asked! Turkeys are allowed through the security checkpoint.— AskTSA (@AskTSA) November 20, 20173. Pies are also good to go. Thanks for checking. Pies are allowed through the security checkpoint. Enjoy!— AskTSA (@AskTSA) November 20, 20174. Strollers are allowed through, just be sure to plan ahead.A stroller is allowed through the security checkpoint. Pls collapse the item and send it into the X-ray for screening. If the item doesn’t fit inside the tunnel, a physical inspection from our officers will be necessary.— AskTSA (@AskTSA) November 20, 20175. In case you’re planning to dress in a Turkey or Santa Claus costume.  Costumes are allowed in carry-on bags. Have a great day!— AskTSA (@AskTSA) November 20, 2017Related: Here Are Some of the Weirdest Things Confiscated at the Airport6. If you’re bringing leftovers back, just make sure they are frozen solid. Good question! Freezer packs, used to keep food cold, must be completely frozen solid when presented for screening.— AskTSA (@AskTSA) November 19, 20177. If you want to commemorate the occasion with help from a selfie stick. Thanks for reaching out! A selfie stick is good to go in carry-on bags.— AskTSA (@AskTSA) November 19, 20178. In case your pet is a member of your family.Thanks for reaching out, Carrie! Small pets are allowed through the security checkpoint, although we advise checking with your airline for their policy. Pls read for more information on traveling w/ pets: https://t.co/QJAD57ubtt— AskTSA (@AskTSA) November 19, 20179. If you want to take a minute away from family togetherness with some video games.Thanks for asking, Taylor. Yes, game consoles are allowed in carry-on bags. Please place this item in a separate bin for X-ray screening. Safe travels!— AskTSA (@AskTSA) November 20, 201710. Lobster stuffing, anyone? TSA says okay.Live lobsters are allowed through security and must be in a clear, plastic, spill proof container. Our officers will visually inspect it at the checkpoint; it should not go through the X-ray machine. Pls contact your airline regarding their policy.— AskTSA (@AskTSA) November 19, 2017Related video: Entrepreneur Elevator Pitch Ep. 9: Simplifying Your Daily Routinecenter_img Nina Zipkin Free Webinar | July 31: Secrets to Running a Successful Family Business 10 TSA-Approved Travel Tips to Make Your Holiday Travel Easier Entrepreneur Staff November 21, 2017 3 min read Staff Writer. Covers leadership, media, technology and culture.last_img read more

Before They Spoiled the Software

first_img –shares Before They Spoiled the Software Learn how to successfully navigate family business dynamics and build businesses that excel. Add to Queue Brought to you by PCWorld Free Webinar | July 31: Secrets to Running a Successful Family Business September 30, 2007 Next Article Software developers would like you to believe that with every new version, their products improve substantially, adding slicker interfaces and more powerful features, and making better use of faster processors and more RAM. As applications mature, they imply, we are all moving toward the Golden Age of Software.But we know that’s not always the case.We’ve all seen programs that started out as a simple 1MB utility become a Jabba-the-Hutt-sized monster with an interface so complex you need a Ph.D. in physics to understand it. We’ve seen software that dropped some of its niftiest features to lure you into buying a more-expensive Pro version. We’ve seen a once-unassuming application become greedy for as much of your system resources as it can grab.Of course, sometimes bloat is in the eye of the beholder. Additions that are great new features for somebody else may be, for you, useless buttons that just get in the way.You don’t have to put up with it, though. We’ve rounded up a list of good software that went bad, and we’ll show you how you can turn back the clock by downloading and installing the earlier, better versions.How We Found ThemFor our compilation of earlier-is-better software, we went to the pros–the people who use plenty of programs every day. We asked our own PC World editors for their lists of applications that were better before developers started mucking around. And we also went to an online treasure trove of older-but-better software–the site OldVersion.com, which has rounded up countless earlier versions of dozens and dozens of programs. We asked site founder and editor Alex Levine to give us his picks of the best oldies, and we asked site users to weigh in as well.Note: When clicking on a link for software at OldVersion.com , you may need to scroll down the resulting page to find the version you want. Also, OldVersion.com isn’t the only site that archives old software. If you’re looking for a hard-to-find older application, try oldapps.com and old-versions.net .The Safety TradeoffBefore we start on our list of Golden Oldies, though, keep in mind one big caveat: An undeniably good thing that comes with new versions of software is the fixes you get for security holes, sometimes very serious ones. So if you choose to run old versions of programs, you are taking a calculated risk. Make sure your other defenses are as strong as you can make them, and be extra careful about what you click.Instant Messaging ProgramsDo you think your instant messaging application is bloated? Welcome to the club.AOL Instant Messenger (AIM)OldVersion.com’s Alex Levine, like many others, complains that the newest version of AIM features more pop-ups, more advertising, and a difficult-to-use interface. “A lot of our users use AIM 5.5.x or 5.9.x simply because [those versions] do what users need the app to do and don’t use as much CPU,” he says.”They made the newer versions way too foofy and filled with [stuff] I don’t need,” one OldVersion user says of AIM. “The older versions work much better; they do just what I want, which is allow me to communicate with people with a minimum of fuss and without a slick interface that I don’t need.””The smilies are unbearable in the newer versions,” another user adds. “Not only do they do that horrible explosion thing, but for some reason you can’t make them any smaller than the default, and the really tiny smilies are so much cuter :).”ICQAmerica Online seems to have a knack for wrecking good instant messengers. ICQ was at one time the big boy of the instant messaging world. Then AOL bought it. Ever since, people have been complaining about the software’s bloat.”I still use ICQ 2003 Pro, primarily because it still has the original single message mode instead of the split chat window,” says PC World’s Elliott Kirschling. “I would prefer to use an even older and less bloated version, but they no longer connect to the newer clients and network.””It used to be a wonderful little IM program, then they just couldn’t leave well enough alone and kept adding more and more,” complains one OldVersion.com user. Oldversion.com has previous versions of both ICQ and ICQ Lite , an even slimmer client. If you want to check out what people are complaining about, you can download ICQ 6 , the current version.Windows Messenger, MSN Messenger, Windows Live MessengerThis Microsoft instant messaging program has gone through so many name changes and incarnations, we defy anyone to name them all. The latest is Windows Live Messenger , which some people complain is a system hog.”Windows Live Messenger is all flair and no guts,” says one OldVersion.com user. “I want a messenger to send messages to people, not eat up my system resources with transparent skins and flashy interfaces.” This IM devotee says he uses, instead, MSN Messenger 7.5 .Media PlayersLooking for a simple media player? You’ll have to go back in time.Windows Media PlayerOnce upon a time, Windows Media Player was a simple, compact application that just played media files. Nothing more, nothing less. Those days are long gone. Today’s Windows Media Player 11 is a major, full-blown application for managing media, with all kinds of bells and whistles. Not everyone, though, likes those bells and whistles.Says one OldVersion.com user: “It used to be a utility that would play media files you had on the computer. Now it’s some unholy bloated ‘Media Center’.” OldVersion.com has versions of Media Player that go all the way back to 5.1 (a mere 0.2MB download!).MusicMatch Jukebox (Now Yahoo Music Jukebox)Yahoo Music Jukebox (the latest version of what used to be MusicMatch Jukebox) manages an unfortunate double-whammy: Critics say it’s both bloated and lacking many of the best features of its predecessor.” Older versions of MusicMatch Jukebox were the best solution for recording, organizing, tagging, and playing a large music collection,” PC World’s Kirschling says. “Version 10 was the last version, and it did get some small updates after Yahoo bought it, but now they are trying to force everyone to ‘upgrade’ to Yahoo Music Jukebox. The problem is that Yahoo Music Jukebox does not have most of the advanced features that MusicMatch has.”I’ll add a personal note here. I used to be a MusicMatch user as well, but I lost interest in it before it was sold to Yahoo, sometime back around version 9, when Big Bloat set in.WinampWhat is it about media players that makes developers want to muck around with them? Do they get a charge out of saying, “My player is bigger than yours”? For whatever reason, these programs grow bigger, not better, with time. Winamp is another player program that has grown through the years, and not necessarily for the better. Older versions were mean and lean, great at playing media and getting out of the way. The new version , some users say, gets in the way.”My favorite version is Winamp 2.95. That’s before they started bulking up the client and adding completely unnecessary things,” says one music aficionado at OldVersion.com. “I just want something that plays my MP3s. I don’t need it to burn CDs for me or download new music or cook my breakfast or massage my feet.”iTunesIn the case of iTunes 7 , bloat isn’t the problem. But discriminating users complain that Apple took away a really useful feature. ” Early versions of iTunes allowed you to stream your music collection to an unlimited number of PCs on a local network,” PC World Senior Editor Eric Dahl explains. “The current version restricts you to five PCs per day, meaning that if your music collection is popular with your coworkers, some of them may get cut off.”QuickTime PlayerQuickTime is another example of Apple taking away features from a perfectly good program, says PC World Executive Editor Allan Stafford. “QuickTime Player got stripped of lots of features in an effort to get people to buy the Pro version.”The current version is QuickTime 7 . Grab older versions here .Image and Video SoftwareSure, this software category usually means big, and bigger, programs. But sometimes you get less, not more.iMovie ’08 (for the Mac)Here’s an example of a great program gone bad–really, really bad. When Apple updated iMovie , it essentially changed the software completely, stripping out all the best features and leaving behind a shell of the former program. So now it doesn’t have a timeline for video editing, its audio editing tools are poor, it won’t accept plug-ins–and that’s just a start.David Pogue wrote in his newsletter for the New York Times, “I can’t remember any software company pulling a stunt like this before: throwing away a fully developed, mature, popular program and substituting a bare-bones, differently focused program under the same name.”Fortunately, the versions of iMovie that were included in Apple iLife 2004 and Apple iLife 2006 are still available through Amazon.com.Corel Paint Shop ProFor many years, Paint Shop Pro was the top piece of graphics shareware. It was the anti-Photoshop–plenty of features, plenty of power, yet simple to use and fast-loading. Then came version 8. Good-bye, simplicity. Things haven’t improved any in the current version, Corel Paint Shop Pro X2 , which costs about $100.”If I want to do something quick and simple, I just use Paint Shop Pro 7,” says one OldVersion.com user. “Paint Shop Pro 8 just tried too hard to be Photoshop Lite.” At least OldVersion.com has trial versions of previous incarnations of Paint Shop Pro .”With 8, they tried to do too much with it and I had no idea how to even use half the features or buttons,” says another OldVersion site user. “I use Paint Shop Pro for basic stuff like cropping, because it loads quicker than Photoshop. For what I need, version 8.0 is practically useless.”ACDSeeEarly versions of ACDSee, an image management program, were slick and fast-loading, and were ideally suited for viewing graphics and doing image conversions. The current version is big and slow, and not nearly as easy to use, many users complain.”Once version 3.0 hit, the application was unsuitable for my use because of all the unnecessary stuff they added,” says one OldVersion.com user.”The older versions of ACDSee loaded in a snap, like the Windows image viewer, [and] had better functions for resizing and slide shows, and also let you do JPG/GIF/BMP/PNG conversions,” another user says.ACDSee 9, the current version, sells for $40. You can find earlier, trial versions at OldVersion.com .And Two More Previous FavoritesThese two applications are popular–but are the current versions the best?Adobe ReaderThis widely used program is designed to do one thing, and one thing alone–let you read Adobe PDF files. Once upon a time that meant a svelte program. Today it means a sumo wrestler. Don’t believe us? Just take a look at the file sizes. Version 2.0 was a 1.4MB download. The current version 8.1 weighs in at a hefty 22.3MB.The best earlier version of this classic, says one OldVersion.com visitor, is Adobe Reader 5.0.5 . “The bloat showed up in version 6,” he says, “and even though it started disappearing in version 8, there’s still a splash screen, annoying updater, and so on.”EudoraLots of long-time PC users have fond memories of this e-mail client; indeed, for many old-timers, it was the first e-mail software they ever used. But some of the changes the program introduced over the years, such as a feature that read your e-mail to warn you if it was potentially insulting, seemed less than necessary to lots of users.Good news may be on the way. Eudora has gone open source, and future versions are being developed by the Mozilla Foundation. You can get the current version here or pick up an earlier version .Our Quick Checklist of Old and New VersionsHere is our complete list of the applications discussed in this article.AIM (current)AIM 5.5.x or 5.9.x (older versions)ICQ 6 (current)ICQ (earlier versions)ICQ Lite (old versions)Windows Live Messenger (current)MSN Messenger 7.5 (earlier version of Live Messenger)Windows Media Player 11 (current)Media Player (earlier versions)Yahoo Music Jukebox (current; formerly MusicMatch)MusicMatch Jukebox (older versions)Winamp (current)Winamp (older versions)iTunes 7 (current)iTunes (early versions)QuickTime 7 (current)QuickTime (older versions)iMovie (current)iMovie, Apple iLife 2004iMovie, Apple iLife 2006Corel Paint Shop Pro X2 (current)Corel Paint Shop Pro, trialware of earlier versionsACDSee 9 (current)ACDSee (earlier, trial versions)Adobe Reader 8.1 (current)Adobe Reader 5.0.5Eudora, current versionEudora, earlier versions Technology Sometimes a program’s new version is actually worse than the previous one. Here are 13 apps we liked better before they were “improved”–plus tips on finding the earlier editions. Register Now » 11 min readlast_img read more

Rising Focus by Businesses to Increase Customer Satisfaction and Optimize Supply Chain

first_imgRising Focus by Businesses to Increase Customer Satisfaction and Optimize Supply Chain Will Significantly Propel the Growth of Enterprise Software Market: IndustryARC PRNewswireJune 24, 2019, 8:26 pmJune 24, 2019 Enterprise software is witnessing huge demand from across a spectrum of applications like enterprise content management (ECM), IT service management (ISM), customer relationship management (CRM), enterprise resource planning (ERP), and business intelligence. Adoption of these Enterprise software increases efficiency and accelerates the overall productivity of an organization; thus, witnessing driving adoption of Enterprise software. The ERP enterprise software segment is projected to grow at a CAGR of 7.53% during forecast period 2019-2025 driven by retail segment in particular. The marketing and CRM segment of the enterprise software market is witnessing high demand and it is expected to grow at a CAGR of 7.21%. Small organizations are largely integrating cloud-based technology into their businesses to lower upfront costs and access business-critical applications conveniently.  Companies are widely adopting cloud-based enterprise software to scale up the businesses with minimum CAPEX investment. By 2019, approximately 75-80% of enterprises will deploy at least one enterprise computing application on the cloud. IT spending on enterprise software was increased at a rate of 9% during 2017-18, where most of these spending were specific to cloud-based enterprise technology.According to the US Small Business Administration, there are 30.2 billion small and medium sized businesses in the country, many of whom use enterprise software to reduce costs and complexity involved in internal technological systems. In 2019, the U.S. holds more than 60% of global cloud spending.  The large presence of hyper scale data centers in the U.S. is the key factor to hold dominant market share for cloud-based technology. This leads to rising demand for cloud-based enterprise software in the U.S. and hence, the region contributes nearly 25% market share in the global enterprise software market.Marketing Technology News: P&G’s Marc Pritchard and Brand Leaders from Taco Bell and LEGO Take on the Future of Advertising, Platforms and Purpose at Wake up with the EconomistTo access / purchase the full report browse the link belowThe enterprise software market is poised to grow at a rapid pace owing to wide range of applications in supply chain and maintaining customer relationship. The global supply chain management market grew by 13.9% in 2017 and reached $12.2 Billion. Organizations are adopting cloud-based Supply Chain Management (SCM) solutions to enable new digitally-based business models to optimize their supply chain, reduce operation cost and increase profitability at rapid pace. Cloud-based SCM applications are designed to flex and scale according to the needs of globally distributed supplier networks, thus enabling organizations to be more responsive to market demands. The growth in these supply chain management Enterprise Software is driving the total Enterprise Software Market is forecast to reach $545m by 2025 and is estimated to grow at a CAGR of 6.15% during the forecast period 2019-2025.Enterprise Software Market Growth Drivers:Rise in the need for good customer experience: Enterprise software helps in easing the customer relationship management processes, which enhances the customer experience and increases customer retention rate. According to the annual report by Facebook Inc., monthly active users (MAUs) of Facebook were 2.32 billion in December 31, 2018, an increase of 9% year-over-year and also the company recorded 37% increase in revenue during 2017-2018 showcasing the prolific rise in social media websites.  The rise in digitization and emergence of social media marketing platforms have increased the need for enterprise software in recording and managing huge amounts of customer data for businesses. Moreover, for businesses, enterprise software eases the creation of personalized marketing content for customers.Emergence of E-Commerce across Sectors: E-commerce websites minimize the lead time, and establish direct business relationship with end customers across various sectors. According to the report published by Walmart, the Flipkart group is showing a significant growth, with its growth merchandise value increasing by 12 times from 2014 to 2018, reaching $7.5 Billion. Organizations require customized enterprise software to manage and analyze customer data, which further widens the scope for opportunities in the global enterprise software market.Marketing Technology News: Will Salesforce Customer 360 Arrival Push CRMs and DMPs Out of Equation in 2020?Get a quote of Enterprise Software Market Report from one of our sales representativesR&D Investment and Initiative, Funding:In 2018, Cohesity, a hyperconverged secondary storage company, announced that it had raised $250m in an oversubscribed Series D funding round led by the SoftBank Vision Fund with strong participation from strategic investors like Cisco Investments, Hewlett Packard Enterprise (HPE), and Morgan Stanley Expansion Capital, along with Sequoia Capital and others. This investment is anticipated to increase the enterprise software development activities towards achieving increased operational efficiency and cost reduction, which in turn will drive revenue growth for end users. Additionally, there has been a significant growth in R&D investments into enterprise software in the European region. For instance, in 2018, Dassault Systèmes SE recorded a total expenditure of $337.72m into R&D, which corresponds to 24.6% of their software revenue. This is anticipated to continue in the future, increasing the likeliness of development of effective enterprise software products which can store, analyze, and visualize large amount of data faster and more securely.The Major Players in this Market Include:The major players in this market are SAP AG, Oracle Corporation, Microsoft Corporation, Infor Inc., Kronos Incorporated and IBM Corporation. These companies have been continuously focusing on R&D for enterprise software, both towards addressing security concerns and integration of cloud services for quick processing and analysis of data.In 2018, IBM Corporation partnered with Salesforce in order to integrate their artificial intelligence (AI) platform and deliver an enhanced customer service experience. Salesforce’s in-house AI platform called Einstein and IBM’s cognitive computing technology platform Watson will collaborate to deliver AI-driven recommendations for future actions by companies.Marketing Technology News: WebEngage Partners with Kenscio’s Email Management Solution crmEnterprise Content managementEnterprise softwareERPIT service managementMarketing Technology NewsNews Previous ArticleHOOQ Streams Live and On-Demand Video Content on Brightcove Video PlatformNext ArticleHow to Increase Your Productivity with Proper Time Management?last_img read more

Exercise could reduce risk of falling for older adults with AD

first_img Source:http://www.healthinaging.org/blog/exercise-may-lessen-risk-of-falling-for-older-adults-who-have-alzheimers-disease-and-mental-health-challenges/ Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 29 2018Alzheimer’s disease (AD) is a brain disease that causes changes that kill brain cells. AD is a type of dementia, which causes memory loss and problems with thinking and making decisions. People with AD and other forms of dementia have difficulties performing the daily activities others might consider routine.Dementia takes a toll on those who live with it–and it also places a burden on caregivers. Along with problems connected to memory, language, and decision-making, dementia can cause neuropsychiatric symptoms, such as depression, anxiety, changes in mood, increased irritability, and changes in personality and behavior. People who have AD/dementia also have twice the risk for falls compared to people without dementia. About 60 percent of older adults with dementia fall each year.Related StoriesRegular physical activity can be effective in reducing pain from arthritisResearchers identify molecular pathway underpinning exercise and improved motor learningExtremely strenuous exercise can overload the heart without increasing cardiac riskResearchers suggest that having neuropsychiatric symptoms might predict whether an older person with AD/dementia is more likely to have a fall. We also know that exercise can reduce the number of falls in older adults with dementia. However, we don’t know very much about how neuropsychiatric symptoms may increase the risk of falls, and we know even less about how exercise may reduce the risk of falls for people with dementia and neuropsychiatric symptoms. A research team decided to explore whether exercise could reduce the risk of falling among community-dwelling people with AD who also had neuropsychiatric symptoms.To learn more, the researchers reviewed a study that investigated the effects of an exercise program for older adults with AD (the FINALEX trial). The study included a range of people living with different stages of AD/dementia and with neuropsychiatric symptoms. Their findings were published in the Journal of the American Geriatrics Society.The original FINALEX study examined and compared older adults who had home- or group-based exercise training with people who didn’t exercise but who received regular care. The researchers learned that the people who exercised had a lower risk for falls than those who didn’t exercise. There was also a higher risk for falls among those who had lower scores on psychological tests and who didn’t exercise.This study revealed that people with AD/dementia and neuropsychiatric symptoms such as depression and anxiety have a higher risk for falls. Exercise can reduce the risk of falling for older adults with these symptoms. Further studies are needed to confirm these results.last_img read more

Researchers for first time view serotonin activating its receptor using highpowered microscopes

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 2 2018Serotonin (3A) receptors are common drug targets in the treatment of pain, gastrointestinal dysfunctions, and mood disorders yet little is known about their three-dimensional structure. Details about serotonin receptor structures could provide important clues to designing better drugs with less side effects. Now, a team of researchers from Case Western Reserve University School of Medicine have used high-powered microscopes to view serotonin activating its receptor for the first time. Images published in Nature reveal molecular details about the receptor that could improve drug design to treat a multitude of diseases.Serotonin receptors sit in cell membranes throughout the body, including the brain, stomach, and the associated nervous system. Drugs that inhibit serotonin receptors help control post-operative nausea, support cancer therapies, and are used to treat gastrointestinal conditions like irritable bowel syndrome. These inhibitors also find application as anti-depressants, and promote attention and memory.Broad application comes with side effects–in part due to suboptimal drug-receptor interactions, says study lead Sudha Chakrapani, PhD, associate professor of physiology and biophysics at Case Western Reserve University School of Medicine. “Successful design of safer therapeutics has been slowed because there is a limited understanding of the structure of the serotonin receptor itself, and what happens after serotonin binds to it. Our work is the first to describe how serotonin activates the full-length serotonin receptor at a level of detail to nearly the individual atom.”Using Nobel Prize-winning microscope technology, Chakrapani’s team studied serotonin as it interacted with its receptor. Their images show serotonin attaching to the receptor and twisting open the channel. Open channels allow molecules to travel from outside the cell to inside. The researchers used simulations to watch as sodium molecules traveled through newly opened channels. The new study highlights distinct conformations of the serotonin receptor that would make a cell more or less permeable to certain molecules–a key insight for drug developers. It also shows which portions of the receptor are most critical for proper channel function.Related StoriesDrinking Matcha tea may reduce anxious behavior, research showsResearchers report how a popular antidepressant drug could rewire the brainNew biological mechanism may explain heightened somatic awarenessThe entire serotonin-receptor occurs in a space about a few billionths of a meter across. Microscopes have only recently evolved to capture such tiny molecules. Cutting-edge technology in the new study–cryo-electron microscopy–earned a 2017 Nobel Prize in chemistry. It uses high-powered microscopes to take snapshots of proteins in action, and compiles them into three-dimensional structural models. In the past year it has already helped Case Western Reserve researchers view structures for proteins central to kidney stones and other ailments. Chakrapani used “cryo-EM” last year to view the serotonin receptor alone, laying the foundation for the present study.The researchers hope their findings could lead to more precise drugs that target specific regions or functions of serotonin receptors. “It’s likely that new and different drugs can work as effective serotonin inhibitors, especially if they’re designed to work differently than current drugs,” says first author Sandip Basak, PhD, postdoctoral fellow in Chakrapani’s lab. “We’re actively pursuing these approaches to help design safer therapeutics that modulate the serotonin receptor to treat a range of conditions.”Source: http://casemed.case.edu/cwrumed360/news-releases/release.cfm?news_id=1541&news_category=8last_img read more

Patients receiving drug therapy before LVAD implantation have high risk of rightsided

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jun 11 2019Patients with left-sided heart failure who get implanted devices to improve the pumping of their hearts may be more likely to develop heart failure on the opposite side of their hearts if they are pre-treated with off-label selective vasodilator drugs, according to new research published in Circulation: Heart Failure, an American Heart Association journal.Between 10% and 40% of patients who undergo left-ventricular assist device (LVAD) implantation for left-sided heart failure develop right-sided heart failure — a complication that spells worse outcomes. To head off the complication, physicians sometimes prescribe preemptive treatment with off-label selective vasodilator drugs called phosphodiesterase-5 inhibitors (PDE5i). PDE5i drugs are currently approved for use to avoid right heart failure in patients with pulmonary arterial hypertension due to causes other than heart disease, which is a different patient group from the ones followed in this study.PDE5i drugs dilate the pulmonary artery — the large vessel that carries blood away from the heart’s right side and into the lungs. A handful of small studies have shown a possible benefit to this off-label approach in some patients but affirmative data from large-scale studies have been lacking and the current study hopes to help close this gap.An LVAD is a mechanical heart pump. It’s placed inside a person’s chest, where it helps the heart pump oxygen-rich blood throughout the body. Unlike an artificial heart transplant, LVADs do not replace the heart. LVADs help the heart do its job.The findings of the new study — the largest analysis to date to assess the utility of this approach — call the preemptive treatment with PDE5i drugs into question. Related StoriesStroke should be treated 15 minutes earlier to save lives, study suggestsWeightlifting is better for the heart than cardioStudy explores role of iron in over 900 diseasesThe results are based on analysis of 11,544 U.S. LVAD recipients who underwent implantation between 2012 and 2017. Of all device recipients, 1,199 (10%) received pre-implantation treatment with PDE5i drugs which target the pulmonary artery to reduce the pressure in the heart’s right ventricle. Overall, 24% of all patients who got LVAD implants developed right-sided heart failure, but the group that got pre-implantation drugs did so at higher rates. To minimize the possible effects of other factors that could bias the outcomes, the researchers matched 1,177patients treated with PDE5i drugs to group of 1,177 patients who did not receive such preventive therapy but were otherwise similar to the pre-treated group in terms of disease severity, age and the presence of other diseases that could affect outcome and health status.Compared with those who did not get drug therapy, the group that received vasodilator drugs before LVAD implantation were 31% more likely to develop right-sided heart failure (29% for those treated, compared with 24% among those who did not receive pre-treatment). Additionally, the relative risk of bleeding within a week of LVAD surgery was 46% higher in patients receiving PDE5i therapy (12% of patients receiving therapy versus 8% of those not receiving this therapy), the analysis showed.Source: American Heart AssociationJournal reference:Gulati, G. et al. (2019) Preimplant Phosphodiesterase-5 Inhibitor Use Is Associated With Higher Rates of Severe Early Right Heart Failure After Left Ventricular Assist Device Implantation. Circulation: Heart Failure. doi.org/10.1161/CIRCHEARTFAILURE.118.005537. We found no benefit of this therapy in patients receiving LVAD devices, including patients with pulmonary vascular disease or right ventricular dysfunction — the very patients who might be expected to benefit most. Our findings should give pause to clinicians considering this therapy, and we would caution against routine use of these therapies prior to LVAD surgery.”Michael Kiernan, M.D., M.S., Study Senior Investigator, Cardiologist, Tufts Medical Center and Assistant Professor of Medicine at Tufts University School of Medicine in Bostonlast_img read more