USA TodayAfter a two week hiatus, the Duke Blue Devils are back in the Top 25 after dropping out of the polls for the first time in eight years on February 1. Duke has been playing better as of late, and secured a massive win over then-No. 7 Virginia on Saturday thanks to a controversial buzzer beater by Grayson Allen, launching them back into the two Top 25 polls.Here’s the far baseline view of Grayson Allen’s shot pic.twitter.com/I0vb4BQTc3— The Cauldron (@TheCauldron) February 13, 2016At the top of the polls, Villanova hangs on at No. 1 for the second straight week after comfortable wins at DePaul and vs. St. John’s. The Wildcats may not be an overwhelming No. 1, but with their only losses coming to Oklahoma, Virginia, and in overtime to Providence, they are consistent in a year that’s been anything but for the college basketball world.Here is the full AP Top 25:1. Villanova 2. Kansas 3. Oklahoma4. Iowa 5. North Carolina 6. Maryland 7. Virginia T-8. Xavier T-8. Michigan State 10. West Virginia11. Miami (FL) 12. Arizona13. Iowa State 14. Kentucky 15. Dayton 16. Oregon 17. Purdue 18. Louisville 19. Notre Dame20. Duke 21. SMU 22. Indiana23. Providence 24. Texas25. BaylorHere is the USA Today Coaches’ Poll:1. Villanova 2. Kansas 3. Oklahoma4. North Carolina 5. Maryland 6. Iowa 7. Xavier 8. Virginia 9. Michigan State 10. Miami (FL)11. West Virginia12. Arizona13. Dayton 14. Kentucky 15. Iowa State16. Purdue 17. Oregon 18. Notre Dame 19. Duke 20. Providence 21. Indiana22. Baylor23. South Carolina24. Texas A&M25. Texas
The Government has set aside more than $16 million for the Jamaica Anti-doping Commission (JADCO) to conduct in and out of competition testing and public education programmes.This was disclosed by Minister with responsibility for Sport, Hon. Natalie Neita Headley, while making her contribution to the 2013/14 Sectoral Debate in the House of Representatives on Wednesday, June 5.She said the figure represents an almost 14 per cent increase in budgetary allowance and speaks to the Government’s commitment to the world-wide fight against doping in sport.“We will continue to implement measures, through JADCO and other related agencies, that will foster dope-free sport at all levels,” she stated.She informed that the allocation will also facilitate the commencement of the collection of blood samples during this fiscal year.The Sport Minister noted that since 2012, the Government has almost tripled the budgetary support to JADCO to guarantee the integrity of Jamaica’s anti-doping system.This increase in allocation, she said, allowed the Commission to increase the number of tests conducted in the 2012/13 financial year by 110 per cent over the previous year.“The Government supports the principle that sport is the expression of one’s true self and the realisation of one’s own unique natural potential. Being successful in sport requires the right attitude, practice, time and effort. The giving of one’s best is good enough,” she remarked.Contact: Athaliah Reynolds-Baker
The Canadian PressWINNIPEG – Police in Winnipeg say that four out of five missing persons reports they receive are about young girls in the care of Manitoba Child and Family Services.The numbers are in a report prepared for the police board.The report says city police get an average of 550 missing persons reports a month.Just over 80 per cent are about kids in government care and 71 per cent are girls.Another police report prepared for the board shows the top 19 missing persons locations are all CFS facilities.Federal government statistics show Manitoba has the highest number of missing persons reports per capita in Canada.“Habitual/chronic” missing persons account for almost 70 per cent of all 709 reports between April and June, the Winnipeg police report stated.“The vast majority of missing persons reported are short-term chronic runaways,” the report said. “Most are vulnerable Indigenous youth who are in the care of Child and Family Services.”
We have combined our intravascular device experience with our knowledge of micro‑optics, systems engineering and AI, in conjunction with external manufacturing partners. The result is an economically viable, disposable camera system that is small enough to fit into the working channel of a typical vascular catheter.”Simon Karger, Cambridge Consultants. Oct 9 2018Breakthrough innovation specialist Cambridge Consultants today announced a watershed moment for intravascular surgery, with the demonstration of a single-use, high-definition miniature camera. Called ‘Leap’, the technology allows a digital view inside veins and arteries for the first time.Leap builds on the latest generation of sub-millimeter cameras, enabling surgeons to visualize parts of the anatomy that are currently inaccessible with today’s imaging techniques.With potential for even smaller cameras on the horizon, this highly miniaturized ‘chip-on-tip’ architecture features a 400 x 400 pixel image (0.16 megapixels) as a standard capability, an order of magnitude improvement over standard fiber-optic angioscopes.Chip-on-tip refers to the location of the imaging sensor at the distal end of the endoscope, in contrast to traditional fiber bundles which transmit light to large, external processing towers.In the future, Leap technology could be combined with Cambridge Consultants’ ‘super-resolution’ image processing to increase the resolution further to 1600 x 1600 pixels (2.6 megapixels).This state-of-the-art, proprietary technique harnesses deep learning to enhance low-resolution images without the blurring associated with traditional upscaling and will ultimately provide visualization for the most challenging cardiovascular surgery.Despite the ability to provide unique predictive information, current surgical endoscopes are not widely used in angioscopy due to poor flexibility, a limited field of view and low resolution.At 1.35 mm in diameter, the Leap early prototype is small and flexible enough for use in a procedure such as intracoronary angioscopy.Leap increases the information available to surgeons with new functionality, such as enabling tissue classification or direct imaging of non-standard vascular occlusions.Related StoriesNew system for precise navigation through the vascular systemTen-fold rise in tongue-tie surgery for newborns ‘without any real strong data’UT Dallas adds MILabs Hybrid OI/CT system to its innovative medical imaging solutionsMoving beyond the traditional endoscope, inspection with a Leap device could be paired with today’s leading technologies, such as IVUS (Intravascular Ultrasound) and OCT (Optical Coherence Tomography), enabling enhanced diagnostic techniques during surgery.Existing endoscopes also carry an elevated risk of infection and device damage due to inadequate sterilization between procedures.Leap overcomes a number of these barriers, being an inexpensive, single-use endoscope and can be operated from a standard computer, not relying on the availability of large and expensive operating room infrastructure.Due to the falling costs of chip-on-tip technology, the expense associated with traditional endoscope systems are set to significantly reduce. This is achieved with the introduction of an economical, reposable device, removing the need for sterilization and maintenance. “For the first time, Leap offers practical, direct visualization in the procedure room and a platform for integration of new configurations, sensor types and imaging modalities (such as spectroscopy). This can enable a new level of advanced imaging in intravascular procedures and an unparalleled surgical experience,” Simon added.Leap will be showcased at Asia Pacific MedTech Forum 2018 in Singapore, October 9th to 10th, Stand 25. News-Medical will also be releasing a follow-up interview as part of our Insights from Industry series in a few weeks time. Source:https://www.cambridgeconsultants.com/
Source:http://www.healthinaging.org/blog/exercise-may-lessen-risk-of-falling-for-older-adults-who-have-alzheimers-disease-and-mental-health-challenges/ Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 29 2018Alzheimer’s disease (AD) is a brain disease that causes changes that kill brain cells. AD is a type of dementia, which causes memory loss and problems with thinking and making decisions. People with AD and other forms of dementia have difficulties performing the daily activities others might consider routine.Dementia takes a toll on those who live with it–and it also places a burden on caregivers. Along with problems connected to memory, language, and decision-making, dementia can cause neuropsychiatric symptoms, such as depression, anxiety, changes in mood, increased irritability, and changes in personality and behavior. People who have AD/dementia also have twice the risk for falls compared to people without dementia. About 60 percent of older adults with dementia fall each year.Related StoriesRegular physical activity can be effective in reducing pain from arthritisResearchers identify molecular pathway underpinning exercise and improved motor learningExtremely strenuous exercise can overload the heart without increasing cardiac riskResearchers suggest that having neuropsychiatric symptoms might predict whether an older person with AD/dementia is more likely to have a fall. We also know that exercise can reduce the number of falls in older adults with dementia. However, we don’t know very much about how neuropsychiatric symptoms may increase the risk of falls, and we know even less about how exercise may reduce the risk of falls for people with dementia and neuropsychiatric symptoms. A research team decided to explore whether exercise could reduce the risk of falling among community-dwelling people with AD who also had neuropsychiatric symptoms.To learn more, the researchers reviewed a study that investigated the effects of an exercise program for older adults with AD (the FINALEX trial). The study included a range of people living with different stages of AD/dementia and with neuropsychiatric symptoms. Their findings were published in the Journal of the American Geriatrics Society.The original FINALEX study examined and compared older adults who had home- or group-based exercise training with people who didn’t exercise but who received regular care. The researchers learned that the people who exercised had a lower risk for falls than those who didn’t exercise. There was also a higher risk for falls among those who had lower scores on psychological tests and who didn’t exercise.This study revealed that people with AD/dementia and neuropsychiatric symptoms such as depression and anxiety have a higher risk for falls. Exercise can reduce the risk of falling for older adults with these symptoms. Further studies are needed to confirm these results.
Reviewed by James Ives, M.Psych. (Editor)Nov 2 2018Serotonin (3A) receptors are common drug targets in the treatment of pain, gastrointestinal dysfunctions, and mood disorders yet little is known about their three-dimensional structure. Details about serotonin receptor structures could provide important clues to designing better drugs with less side effects. Now, a team of researchers from Case Western Reserve University School of Medicine have used high-powered microscopes to view serotonin activating its receptor for the first time. Images published in Nature reveal molecular details about the receptor that could improve drug design to treat a multitude of diseases.Serotonin receptors sit in cell membranes throughout the body, including the brain, stomach, and the associated nervous system. Drugs that inhibit serotonin receptors help control post-operative nausea, support cancer therapies, and are used to treat gastrointestinal conditions like irritable bowel syndrome. These inhibitors also find application as anti-depressants, and promote attention and memory.Broad application comes with side effects–in part due to suboptimal drug-receptor interactions, says study lead Sudha Chakrapani, PhD, associate professor of physiology and biophysics at Case Western Reserve University School of Medicine. “Successful design of safer therapeutics has been slowed because there is a limited understanding of the structure of the serotonin receptor itself, and what happens after serotonin binds to it. Our work is the first to describe how serotonin activates the full-length serotonin receptor at a level of detail to nearly the individual atom.”Using Nobel Prize-winning microscope technology, Chakrapani’s team studied serotonin as it interacted with its receptor. Their images show serotonin attaching to the receptor and twisting open the channel. Open channels allow molecules to travel from outside the cell to inside. The researchers used simulations to watch as sodium molecules traveled through newly opened channels. The new study highlights distinct conformations of the serotonin receptor that would make a cell more or less permeable to certain molecules–a key insight for drug developers. It also shows which portions of the receptor are most critical for proper channel function.Related StoriesDrinking Matcha tea may reduce anxious behavior, research showsResearchers report how a popular antidepressant drug could rewire the brainNew biological mechanism may explain heightened somatic awarenessThe entire serotonin-receptor occurs in a space about a few billionths of a meter across. Microscopes have only recently evolved to capture such tiny molecules. Cutting-edge technology in the new study–cryo-electron microscopy–earned a 2017 Nobel Prize in chemistry. It uses high-powered microscopes to take snapshots of proteins in action, and compiles them into three-dimensional structural models. In the past year it has already helped Case Western Reserve researchers view structures for proteins central to kidney stones and other ailments. Chakrapani used “cryo-EM” last year to view the serotonin receptor alone, laying the foundation for the present study.The researchers hope their findings could lead to more precise drugs that target specific regions or functions of serotonin receptors. “It’s likely that new and different drugs can work as effective serotonin inhibitors, especially if they’re designed to work differently than current drugs,” says first author Sandip Basak, PhD, postdoctoral fellow in Chakrapani’s lab. “We’re actively pursuing these approaches to help design safer therapeutics that modulate the serotonin receptor to treat a range of conditions.”Source: http://casemed.case.edu/cwrumed360/news-releases/release.cfm?news_id=1541&news_category=8
Dev Ankur Wadhawan ChuruJuly 16, 2019UPDATED: July 16, 2019 11:39 IST (Image for Representation)The Churu custodial death and alleged gang rape have snowballed into a major controversy for the Ashok Gehlot-led Rajasthan government. Bharatiya Janata Party (BJP), the principal opposition party in Rajasthan, raised the matter in the state assembly on Monday, demanding a CBI inquiry.”A Dalit youth was beaten to death and from the minister’s statement, it is clear that he was in police custody. And after that, his sister-in-law is raped. And the complaint of the rape was given to the chief minister and director general of police. So far no police personnel have been arrested. We demand a CBI investigation,” Rajendra Rathore, senior BJP leader, said.A 35-year-old Dalit woman was allegedly kept confined inside the police station for several days, was tortured and gangraped in police custody in Rajasthan’s Churu district. This, the woman has alleged, happened after her brother-in-law was picked up by the police in a case of theft. He was allegedly tortured and beaten to death in police custody.”My wife was beaten up for three days by the police,” the complainant’s husband said.The case was handed over to the CID Crime Branch. A case was filed against the station house officer of Sardarshahar police station apart from five to six other police personnel. The case has been filed on the basis of a report filed by CID Crime Branch under various sections of the Indian Penal Code and SC/ST Act.”Investigation is on. On the basis of statement, a case has been registered against the then SHO Sardarshahar and some policemen under Section 376 of the IPC and SC/ST Act,” Prakash Sharma, additional SP, Churu, said.The woman, in her complaint, has mentioned that the police had picked up her brother-in-law on allegation of theft. She has alleged that after her brother-in-law, she was also picked up by the police. After consuming alcohol five to six policemen beat her up, plucked out her nails and eight police personnel, including the SHO, raped her.Eight policemen including the Sardarshahar SHO, a head constable and six constables have been suspended; the Churu Superintendent of Police, Rajendra Kumar, has been removed from his post.Following this, the BJP demanded CBI inquiry into Churu custodial death and gang rape.However, Congress MLA from Sardarshahar Bhanwarlal Sharma, has claimed that the 35-year-old Dalit woman was not gangraped by policemen.Sharma also said that the man who died in police custody was a petty thief who had sustained injuries after being beaten up by the villagers.ALSO READ: Sardarshahar policemen booked for torturing, gangraping woman whose brother-in-law died in custodyALSO WATCH: Ram Rahim parole: Why is the Khattar government backing rapist parole?Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShreya Sinha BJP demands CBI inquiry into Churu custodial death, gang rape The Churu custodial death and alleged gang rape have snowballed into a major controversy for the Ashok Gehlot-led Rajasthan government. Bharatiya Janata Party (BJP), the principal opposition party in Rajasthan, raised the matter in the state assembly on Monday, demanding a CBI inquiry.advertisement Next